The Water-Energy-Food nexus has been central in discussions on sustainable development[1]. Socio-economic development and population growth pose unique challenges in securing sufficient water, energy, and food. These challenges will become increasingly demanding in order to meet the expected demand of 50% more food, 40% more energy, and 30% more water by 2030[2] [3] [4]. More than 2 billion people are living with the risk of reduced access to freshwater resources and by 2050, at least one in four people is likely to live in a country affected by chronic or recurring shortages of fresh water[5]. Clean water for all is one of the 17 UN development goals, with one of the targets being to substantially increase water-use efficiency across all sectors. Agriculture is the largest user of freshwater, which is essential for food production, but also for biochemical and biofuels production, as we are moving towards a bio-based society. Hence, lack of fresh water and salinization of soils are at the core of the Water-Energy-Food nexus  and represents major challenges to meet several of the 17 UN development goals. Sustainable Aquaculture and halophyte farming development – like suggested in the AQUACOMBINE project – could directly contribute to meeting goals: (2) Zero hunger, (3) Good health and wellbeing, (6) Clean water, (7) Affordable and clean energy, (8) Decent work and economic growth, (9) Industry, innovation, and infrastructure, (12) Responsible production and consumption, (14) Life below water, (15) Life on land (Figure 15).